Issue 25, 2013
From the journal:

Chemical Communications

High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor†

Kehua Xu,a   Feng Wang,a   Xiaohong Pan,ab   Renpu Liu,a   Jing Ma,a   Fanpeng Konga  and  Bo Tang*a  

* Corresponding authors

a College of Chemistry, Chemical Engineering and Materials Science, Engineering Research Center of Pesticide and Medicine Intermediate Clean Production, Ministry of Education, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China
E-mail: tangb@sdnu.edu.cn
Fax: +86 531-8618-0017

b Department of Pharmaceutical Sciences, Binzhou Medical University, Yantai 264003, Shandong, P. R. China

Abstract

A highly selective and sensitive near-infrared (NIR) fluorescence probe (Cy-NO2) for imaging nitroreductase was developed and was successfully applied to investigating the relationship between epithelial–mesenchymal transitions (EMTs) in tumour progression and intracellular hypoxic level.

Graphical abstract: High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

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Article information

DOI
https://doi.org/10.1039/C3CC38980D
Article type
Communication
Submitted
16 Dec 2012
Accepted
10 Feb 2013
First published
11 Feb 2013

Chem. Commun., 2013,49, 2554-2556

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High selectivity imaging of nitroreductase using a near-infrared fluorescence probe in hypoxic tumor

K. Xu, F. Wang, X. Pan, R. Liu, J. Ma, F. Kong and B. Tang, Chem. Commun., 2013, 49, 2554 DOI: 10.1039/C3CC38980D

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