Issue 28, 2013
From the journal:

Chemical Communications

Making Bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(iii) acetylsalicylate†

Philip C. Andrews,*a   Victoria L. Blair,a   Richard L. Ferrero,b   Peter C. Junkc  and  Ish Kumara  

* Corresponding authors

a School of Chemistry, Monash University, Clayton, Melbourne, Australia
E-mail: phil.andrews@monash.edu

b Monash Institute of Medical Research, Centre for Innate Immunity and Infectious Diseases Monash University, Clayton, Melbourne, Australia

c School of Pharmacy and Molecular Sciences, James Cook University, Townsville, Australia

Abstract

Reaction of Bi(OtBu)3 with aspirin (acetylsalicylic acid = aspH) in dry toluene results in the bismuth(III) complex, [Bi(O2C(C6H4)OAc)3]∞ 1 (O2C(C6H4)OAc = asp), minimum inhibitory concentration (MIC) against Helicobacter pylori ≥ 6.25 μg mL−1, while the inclusion of a stoichiometric equivalent of KOtBu leads to crystals of the bismuthate salt [KBi(O2C(C6H4)OAc)4]∞ 2.

Graphical abstract: Making Bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(iii) acetylsalicylate

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Article information

DOI
https://doi.org/10.1039/C3CC40645H
Article type
Communication
Submitted
25 Jan 2013
Accepted
21 Feb 2013
First published
22 Feb 2013

Chem. Commun., 2013,49, 2870-2872

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Making Bispirin: synthesis, structure and activity against Helicobacter pylori of bismuth(III) acetylsalicylate

P. C. Andrews, V. L. Blair, R. L. Ferrero, P. C. Junk and I. Kumar, Chem. Commun., 2013, 49, 2870 DOI: 10.1039/C3CC40645H

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