Issue 44, 2013
From the journal:

Chemical Communications

RNA binding and inhibition of primer extension by a Ru(iii)/Pt(ii) metal complex†

Swapan S. Jain,*a   Craig M. Anderson,*a   Francesca DiRienzo,a   Isabelle R. Taylor,a   Kyan Jain,a   Sumedha Guhaa  and  Nushrat Hoquea  

* Corresponding authors

a Department of Chemistry, Bard College, 30 Campus Road, Annandale-on-Hudson, USA
E-mail: sjain@bard.edu
Fax: +1 845 752 2339
Tel: +1 845 752 2354

Abstract

AH197, a trinuclear Ru(III)/Pt(II) metal complex, is strikingly more effective than the hallmark anticancer drug cisplatin and the Ru(III) clinical candidate NAMI-A in its binding to RNA and inhibition of primer DNA synthesis. Heteromultinuclear complexes could potentially serve as far better chemotherapeutics than mononuclear complexes.

Graphical abstract: RNA binding and inhibition of primer extension by a Ru(iii)/Pt(ii) metal complex

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Article information

DOI
https://doi.org/10.1039/C3CC40699G
Article type
Communication
Submitted
27 Jan 2013
Accepted
15 Apr 2013
First published
17 Apr 2013

Chem. Commun., 2013,49, 5031-5033

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RNA binding and inhibition of primer extension by a Ru(III)/Pt(II) metal complex

S. S. Jain, C. M. Anderson, F. DiRienzo, I. R. Taylor, K. Jain, S. Guha and N. Hoque, Chem. Commun., 2013, 49, 5031 DOI: 10.1039/C3CC40699G

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