Issue 27, 2013
From the journal:

Chemical Communications

Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity†

Xianjin Xiao,a   Yang Liua  and  Meiping Zhao*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing, China
E-mail: mpzhao@pku.edu.cn
Fax: +86-10-62751708

Abstract

A unique capability of Endonuclease IV in discrimination of mismatches neighboring a natural abasic site in DNA strands has been demonstrated, which enables genotyping of SNPs with high discrimination factors and differentiation of as low as 0.1–0.01% of target DNA strands from a large background of single-base different interfering strands.

Graphical abstract: Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity

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Article information

DOI
https://doi.org/10.1039/C3CC40902C
Article type
Communication
Submitted
02 Feb 2013
Accepted
18 Feb 2013
First published
19 Feb 2013

Chem. Commun., 2013,49, 2819-2821

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Endonuclease IV discriminates mismatches next to the apurinic/apyrimidinic site in DNA strands: constructing DNA sensing platforms with extremely high selectivity

X. Xiao, Y. Liu and M. Zhao, Chem. Commun., 2013, 49, 2819 DOI: 10.1039/C3CC40902C

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