Issue 60, 2013
From the journal:

Chemical Communications

Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition†

Serena Ambrosini,a   Selim Beyazit,a   Karsten Haupt*a  and  Bernadette Tse Sum Bui*a  

* Corresponding authors

a Compiègne University of Technology, CNRS Enzyme and Cell Engineering Laboratory, Rue Roger Couttolenc, CS 60319, 60203 Compiègne Cedex, France
E-mail: karsten.haupt@utc.fr, jeanne.tse-sum-bui@utc.fr
Fax: +33 3 44203910
Tel: +33 3 44234455

Abstract

A solid-phase synthesis approach to prepare molecularly imprinted polymer nanoparticles (MIP-NPs) specific for trypsin is described. The protein is immobilized on a solid support upon which thermoresponsive MIP-NPs are synthesized. The MIP-NPs are released by a simple temperature change, resulting in synthetic antibody mimics exhibiting high specificity and selectivity for trypsin.

Graphical abstract: Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

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Article information

DOI
https://doi.org/10.1039/C3CC41701H
Article type
Communication
Submitted
06 Mar 2013
Accepted
03 Jun 2013
First published
04 Jun 2013

Chem. Commun., 2013,49, 6746-6748

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Solid-phase synthesis of molecularly imprinted nanoparticles for protein recognition

S. Ambrosini, S. Beyazit, K. Haupt and B. Tse Sum Bui, Chem. Commun., 2013, 49, 6746 DOI: 10.1039/C3CC41701H

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