Issue 45, 2013
From the journal:

Chemical Communications

Deubiquitinases as potential anti-cancer targets for gold(iii) complexes†

Jing-Jing Zhang,a   Kwan-Ming Ng,a   Chun-Nam Lok,a   Raymond Wai-Yin Suna  and  Chi-Ming Che*a  

* Corresponding authors

a State Key Laboratory of Synthetic Chemistry, Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China
E-mail: cmche@hku.hk
Fax: +852 2857 1586
Tel: +852 2859 2154

Abstract

A panel of [AuIII(C⁁N)(R2NCS2)]+ (HC⁁N = 2-phenylpyridine) complexes displayed significant deubiquitinases (DUBs) inhibitory activity; one of these complexes showed selective in vitro cytotoxicity towards breast cancer cells correlated to high cellular uptake of gold, and induced cell-cycle arrest, apoptosis, and anti-angiogenic property that could be related to DUB inhibitory activity.

Graphical abstract: Deubiquitinases as potential anti-cancer targets for gold(iii) complexes

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Article information

DOI
https://doi.org/10.1039/C3CC41766B
Article type
Communication
Submitted
08 Mar 2013
Accepted
12 Apr 2013
First published
12 Apr 2013

Chem. Commun., 2013,49, 5153-5155

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Deubiquitinases as potential anti-cancer targets for gold(III) complexes

J. Zhang, K. Ng, C. Lok, R. W. Sun and C. Che, Chem. Commun., 2013, 49, 5153 DOI: 10.1039/C3CC41766B

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