Issue 61, 2013
From the journal:

Chemical Communications

Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources†

Qian Zhang,a   Fan Yang*a  and  Yangjie Wu*a  

* Corresponding authors

a The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou 450052, People's Republic of China
E-mail: yangf@zzu.edu.cn, wyj@zzu.edu.cn
Fax: +86-371-6797-9408
Tel: +86-371-6797-9408

Abstract

A facile and efficient protocol for palladium-catalyzed ortho-acylation of 2-aryl pyridines was developed. Note that this acylation utilized arylmethyl amines as new, cheap and readily available acylation reagents and exhibited high regioselectivity for 2-aryl pyridines bearing a meta-substituent in the aryl ring moiety.

Graphical abstract: Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources

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Article information

DOI
https://doi.org/10.1039/C3CC42106F
Article type
Communication
Submitted
22 Mar 2013
Accepted
18 Apr 2013
First published
18 Apr 2013

Chem. Commun., 2013,49, 6837-6839

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Palladium-catalyzed ortho-acylation of 2-aryl pyridine derivatives using arylmethyl amines as new acyl sources

Q. Zhang, F. Yang and Y. Wu, Chem. Commun., 2013, 49, 6837 DOI: 10.1039/C3CC42106F

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