Issue 45, 2013
From the journal:

Chemical Communications

Reversible chemoselective tagging and functionalization of methionine containing peptides†

Jessica R. Kramera  and  Timothy J. Deming*a  

* Corresponding authors

a Department of Chemistry and Biochemistry, Department of Bioengineering, HS-SEAS, University of California, 5121 Engineering 5, Los Angeles, CA, USA
E-mail: demingt@seas.ucla.edu
Fax: +1 310-794-5956
Tel: +1 310-267-4450

Abstract

Reagents were developed to allow chemoselective tagging of methionine residues in peptides and polypeptides, subsequent bioorthogonal functionalization of the tags, and cleavage of the tags when desired. This methodology can be used for triggered release of therapeutic peptides, or release of tagged protein digests from affinity columns.

Graphical abstract: Reversible chemoselective tagging and functionalization of methionine containing peptides

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Article information

DOI
https://doi.org/10.1039/C3CC42214C
Article type
Communication
Submitted
26 Mar 2013
Accepted
19 Apr 2013
First published
23 Apr 2013

Chem. Commun., 2013,49, 5144-5146

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Reversible chemoselective tagging and functionalization of methionine containing peptides

J. R. Kramer and T. J. Deming, Chem. Commun., 2013, 49, 5144 DOI: 10.1039/C3CC42214C

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