Issue 47, 2013
From the journal:

Chemical Communications

Enantioselective total synthesis of (+)-brazilin, (−)-brazilein and (+)-brazilide A†

Xuequan Wang,a   Hongbin Zhang,*a   Xiaodong Yang,*a   Jingfeng Zhaoa  and  Chengxue Pana  

* Corresponding authors

a Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming, P. R. China
E-mail: zhanghb@ynu.edu.cn, xdyang@ynu.edu.cn
Fax: +86-871-65035538

Abstract

An enantioselective strategy for the synthesis of (+)-brazilin, (−)-brazilein and (+)-brazilide A has been developed. A Lewis acid mediated lactonization established the novel fused bis-lactone core of brazilide A and finalized the first total synthesis of (+)-brazilide A.

Graphical abstract: Enantioselective total synthesis of (+)-brazilin, (−)-brazilein and (+)-brazilide A

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Article information

DOI
https://doi.org/10.1039/C3CC42385A
Article type
Communication
Submitted
02 Apr 2013
Accepted
23 Apr 2013
First published
09 May 2013

Chem. Commun., 2013,49, 5405-5407

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Enantioselective total synthesis of (+)-brazilin, (−)-brazilein and (+)-brazilide A

X. Wang, H. Zhang, X. Yang, J. Zhao and C. Pan, Chem. Commun., 2013, 49, 5405 DOI: 10.1039/C3CC42385A

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