Issue 57, 2013
From the journal:

Chemical Communications

A novel class of polymeric pH-responsive MRI CEST agents†

Shanrong Zhang,ab   Kejin Zhou,a   Gang Huang,a   Masaya Takahashi,b   A. Dean Sherry*bc  and  Jinming Gao*ac  

* Corresponding authors

a Department of Pharmacology, Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
E-mail: jinming.gao@utsouthwestern.edu

b Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
E-mail: dean.sherry@utsouthwestern.edu

c Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75083, USA

Abstract

In this communication, we report that ionizable, tertiary amine-based block copolymers can be used as pH-responsive contrast agents for magnetic resonance imaging (MRI) through the chemical exchange saturation transfer (CEST) mechanism. The CEST signal is essentially “off” when the polymers form micelles near physiological pH but is activated to the “on” state when the micelles dissociate in an acidic environment.

Graphical abstract: A novel class of polymeric pH-responsive MRI CEST agents

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Article information

DOI
https://doi.org/10.1039/C3CC42452A
Article type
Communication
Submitted
04 Apr 2013
Accepted
26 May 2013
First published
28 May 2013

Chem. Commun., 2013,49, 6418-6420

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A novel class of polymeric pH-responsive MRI CEST agents

S. Zhang, K. Zhou, G. Huang, M. Takahashi, A. Dean Sherry and J. Gao, Chem. Commun., 2013, 49, 6418 DOI: 10.1039/C3CC42452A

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