Issue 63, 2013
From the journal:

Chemical Communications

In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy†

Hyla Allouche-Arnon,a   Ayelet Gamliel,a   Jacob Sosna,a   J. Moshe Gomoria  and  Rachel Katz-Brull*a  

* Corresponding authors

a Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
E-mail: rkb@hadassah.org.il
Web: www.katz-brull-lab.org
Fax: +972-2-6777687

Abstract

Real-time monitoring of betaine aldehyde metabolism at high temporal resolution was accomplished using a hyperpolarized choline analog and 13C-NMR. This represents the first observation of an aldehyde intermediate on hyperpolarized MR and opens the way for kinetic studies of oxidase/dehydrogenase enzymes in vitro and in vivo.

Graphical abstract: In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy

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Article information

DOI
https://doi.org/10.1039/C3CC42542H
Article type
Communication
Submitted
08 Apr 2013
Accepted
25 Jun 2013
First published
26 Jun 2013

Chem. Commun., 2013,49, 7076-7078

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In vitro visualization of betaine aldehyde synthesis and oxidation using hyperpolarized magnetic resonance spectroscopy

H. Allouche-Arnon, A. Gamliel, J. Sosna, J. M. Gomori and R. Katz-Brull, Chem. Commun., 2013, 49, 7076 DOI: 10.1039/C3CC42542H

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