Issue 64, 2013
From the journal:

Chemical Communications

A fluorescence off–on reporter for real time monitoring of gemcitabine delivery to the cancer cells†

Sankarprasad Bhuniya,a   Min Hee Lee,a   Hyun Mi Jeon,b   Ji Hye Han,b   Jae Hong Lee,a   Nayoung Park,a   Sukhendu Maiti,a   Chulhun Kang*b  and  Jong Seung Kim*a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr
Fax: +82-2-3290-3121

b The School of East-West Medical Science, Kyung Hee University, Yongin, Korea
E-mail: kangch@khu.ac.kr

Abstract

We present the design, synthesis, optical properties and in vitro biological assessments of the theranostic prodrug 6 in which a near IR fluorophore is conjugated with a cancer cell-directing biotin unit; further it is linked with the anti-cancer drug gemcitabine via a self-immolative spacer, a disulfide bond. The prodrug 6 is able to monitor drug delivery and cellular imaging.

Graphical abstract: A fluorescence off–on reporter for real time monitoring of gemcitabine delivery to the cancer cells

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Article information

DOI
https://doi.org/10.1039/C3CC42653J
Article type
Communication
Submitted
11 Apr 2013
Accepted
07 May 2013
First published
09 May 2013

Chem. Commun., 2013,49, 7141-7143

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A fluorescence off–on reporter for real time monitoring of gemcitabine delivery to the cancer cells

S. Bhuniya, M. H. Lee, H. M. Jeon, J. H. Han, J. H. Lee, N. Park, S. Maiti, C. Kang and J. S. Kim, Chem. Commun., 2013, 49, 7141 DOI: 10.1039/C3CC42653J

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