Issue 72, 2013
From the journal:

Chemical Communications

Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides†

James B. Delehanty,*a   Juan B. Blanco-Canosa,c   Christopher E. Bradburne,a   Kimihiro Susumu,bd   Michael H. Stewart,b   Duane E. Prasuhn,a   Philip E. Dawsonc  and  Igor L. Medintz*a  

* Corresponding authors

a Center for Bio/Molecular Science and Engineering, Code 6900, USA

b Optical Sciences Division, Code 5600, U.S. Naval Research Laboratory, Washington, USA
E-mail: James.delehanty@nrl.navy.mil, igor.medintz@nrl.navy.mil

c Departments of Cell Biology & Chemistry, The Scripps Research Institute, La Jolla, USA

d Sotera Defense Solutions, Annapolis Junction, USA

Abstract

Modular peptides displaying both quantum dot bioconjugation motifs and specific subcellular targeting domains were constructed using a chemoselective aniline-catalyzed hydrazone coupling chemistry. Peptides were ratiometrically assembled onto quantum dots to facilitate their specific delivery to either the plasma membrane, endosomes, the cytosol or the mitochondria of target cells.

Graphical abstract: Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides

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Article information

DOI
https://doi.org/10.1039/C3CC42781A
Article type
Communication
Submitted
15 Apr 2013
Accepted
24 May 2013
First published
12 Jun 2013

Chem. Commun., 2013,49, 7878-7880

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Site-specific cellular delivery of quantum dots with chemoselectively-assembled modular peptides

J. B. Delehanty, J. B. Blanco-Canosa, C. E. Bradburne, K. Susumu, M. H. Stewart, D. E. Prasuhn, P. E. Dawson and I. L. Medintz, Chem. Commun., 2013, 49, 7878 DOI: 10.1039/C3CC42781A

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