Issue 67, 2013
From the journal:

Chemical Communications

Short, terminally modified 2′-OMe RNAs as inhibitors of microRNA†

Jenny Blechinger,a   Hanna Pieper,a   Paul Marzenell,a   Larisa Kovbasyuk,a   Andrius Serva,‡b   Vytaute Starkuviene,b   Holger Erfleb  and  Andriy Mokhir*a  

* Corresponding authors

a Organic Chemistry II, Friedrich-Alexander-University of Erlangen-Nuremberg, Henkestr. 42, 91054 Erlangen, Germany
E-mail: Andriy.Mokhir@fau.de

b BioQuant, Ruprecht-Karls-University of Heidelberg, Im Neuenheimer Feld 267, Heidelberg, Germany

Abstract

We applied 14-mer 2′-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5′-terminus and three 2′-fluoro-2′-deoxynucleotides at the 3′-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.

Graphical abstract: Short, terminally modified 2′-OMe RNAs as inhibitors of microRNA

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Article information

DOI
https://doi.org/10.1039/C3CC43174F
Article type
Communication
Submitted
29 Apr 2013
Accepted
27 Jun 2013
First published
28 Jun 2013

Chem. Commun., 2013,49, 7397-7399

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Short, terminally modified 2′-OMe RNAs as inhibitors of microRNA

J. Blechinger, H. Pieper, P. Marzenell, L. Kovbasyuk, A. Serva, V. Starkuviene, H. Erfle and A. Mokhir, Chem. Commun., 2013, 49, 7397 DOI: 10.1039/C3CC43174F

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