Issue 60, 2013
From the journal:

Chemical Communications

One-pot synthesis of quinazoline derivatives via [2+2+2] cascade annulation of diaryliodonium salts and two nitriles†

Xiang Su,ab   Chao Chen,*a   Yong Wang,ac   Junjie Chen,a   Zhenbang Louac  and  Ming Lic  

* Corresponding authors

a Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: chenchao01@mails.tsinghua.edu.cn
Tel: +86-10-62773684

b College of Chemistry and Biological Engineering, Beijing University of Science and Technology, Beijing, China

c College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, China

Abstract

An efficient one-pot approach to multiple substituted quinazolines with diaryliodonium salt 1, and two nitriles 2 has been presented. The reaction enables great flexibility of the substitution patterns on quinazolines and is applicable to two different nitriles to give a regio-selective product.

Graphical abstract: One-pot synthesis of quinazoline derivatives via [2+2+2] cascade annulation of diaryliodonium salts and two nitriles

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Article information

DOI
https://doi.org/10.1039/C3CC43216E
Article type
Communication
Submitted
01 May 2013
Accepted
06 Jun 2013
First published
07 Jun 2013

Chem. Commun., 2013,49, 6752-6754

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One-pot synthesis of quinazoline derivatives via [2+2+2] cascade annulation of diaryliodonium salts and two nitriles

X. Su, C. Chen, Y. Wang, J. Chen, Z. Lou and M. Li, Chem. Commun., 2013, 49, 6752 DOI: 10.1039/C3CC43216E

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