The mechanism of inhibition by H2 of H2-evolution by hydrogenases

Vincent Fourmond; Carole Baffert; Kateryna Sybirna; Sébastien Dementin; Abbas Abou-Hamdan; Isabelle Meynial-Salles; Philippe Soucaille; Hervé Bottin; Christophe Léger

doi:10.1039/C3CC43297A

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The mechanism of inhibition by H₂ of H₂-evolution by hydrogenases†

Vincent Fourmond,^a Carole Baffert,^a Kateryna Sybirna,^b Sébastien Dementin,^a Abbas Abou-Hamdan,^a Isabelle Meynial-Salles,^c Philippe Soucaille,^c Hervé Bottin^b and Christophe Léger*^a

Author affiliations

* Corresponding authors

^a CNRS, Aix-Marseille Université, BIP UMR 7281, Marseille, France
E-mail: christophe.leger@imm.cnrs.fr
Web: http://bip.cnrs-mrs.fr/bip06, https://twitter.com/BIP6_Marseille
Tel: +33 4 91 16 45 29

^b iBiTec-S SB2SM, LMB (UMR CNRS 8221), DSV, CEA, 91191 Gif-sur-Yvette, France

^c Université de Toulouse, INSA, UPS, INP, LISBP, INRA:UMR792, CNRS:UMR 5504, 135 Avenue de Rangueil, 31077 Toulouse, France

Abstract

By analysing the results of experiments carried out with two FeFe hydrogenases and several “channel mutants” of a NiFe hydrogenase, we demonstrate that whether or not hydrogen evolution is significantly inhibited by H₂ is not a consequence of active site chemistry, but rather relates to H₂ transport within the enzyme.

This article is part of the themed collection: Electrocatalytic hydrogen evolution

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Article information

DOI: https://doi.org/10.1039/C3CC43297A
Article type: Communication
Submitted: 03 May 2013
Accepted: 10 Jun 2013
First published: 10 Jun 2013

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Chem. Commun., 2013,49, 6840-6842

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The mechanism of inhibition by H₂ of H₂-evolution by hydrogenases

V. Fourmond, C. Baffert, K. Sybirna, S. Dementin, A. Abou-Hamdan, I. Meynial-Salles, P. Soucaille, H. Bottin and C. Léger, Chem. Commun., 2013, 49, 6840 DOI: 10.1039/C3CC43297A

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