Issue 70, 2013
From the journal:

Chemical Communications

Enantioselective synthesis of benzofurans and benzoxazinesvia an olefin cross-metathesis–intramolecular oxo-Michael reaction†

Jun-Wei Zhang,ab   Quan Cai,b   Qing Gu,b   Xiao-Xin Shia  and  Shu-Li You*ab  

* Corresponding authors

a School of Pharmacy, East China University of Science and Technology, 130 Mei-Long Road, Shanghai 200237, China

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China
E-mail: slyou@sioc.ac.cn
Fax: +86 21-54925087

Abstract

Chiral phosphoric acid and Hoveyda–Grubbs II were found to catalyze an olefin cross-metathesis–intramolecular oxo-Michael cascade reaction of the ortho-allylphenols and enones to provide a variety of benzofuran and benzoxazine derivatives in moderate to good yields and enantioselectivity.

Graphical abstract: Enantioselective synthesis of benzofurans and benzoxazines via an olefin cross-metathesis–intramolecular oxo-Michael reaction

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Article information

DOI
https://doi.org/10.1039/C3CC43937B
Article type
Communication
Submitted
25 May 2013
Accepted
02 Jul 2013
First published
02 Jul 2013

Chem. Commun., 2013,49, 7750-7752

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Enantioselective synthesis of benzofurans and benzoxazines via an olefin cross-metathesis–intramolecular oxo-Michael reaction

J. Zhang, Q. Cai, Q. Gu, X. Shi and S. You, Chem. Commun., 2013, 49, 7750 DOI: 10.1039/C3CC43937B

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