Issue 61, 2013
From the journal:

Chemical Communications

Direct 2-acetoxylation of quinoline N-oxidesvia copper catalyzed C–H bond activation†

Xuan Chen,a   Chongwei Zhu,a   Xiuling Cui*ab  and  Yangjie Wu*a  

* Corresponding authors

a Department of Chemistry, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, Zhengzhou University, Zhengzhou, P. R. China
E-mail: cuixl@zzu.edu.cn, wyj@zzu.edu.cn
Tel: +86 371-67767753

b School of Biomedical Sciences, Engineering Research Center of Molecular Medicine of Chinese Education Ministry, Xiamen Key Laboratory of Ocean and Gene Drugs, Institute of Molecular Medicine of Huaqiao University, Huaqiao University, Xiamen, P. R. China

Abstract

An efficient and direct 2-acetoxylation of quinoline N-oxides via copper(I) catalyzed C–H bond activation has been developed. This transformation was achieved using TBHP as an oxidant in the cross-dehydrogenative coupling (CDC) reaction of quinoline N-oxides with aldehydes, and provided a practical pathway to 2-acyloxyl quinolines.

Graphical abstract: Direct 2-acetoxylation of quinoline N-oxides via copper catalyzed C–H bond activation

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Article information

DOI
https://doi.org/10.1039/C3CC43947J
Article type
Communication
Submitted
26 May 2013
Accepted
11 Jun 2013
First published
12 Jun 2013

Chem. Commun., 2013,49, 6900-6902

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Direct 2-acetoxylation of quinoline N-oxides via copper catalyzed C–H bond activation

X. Chen, C. Zhu, X. Cui and Y. Wu, Chem. Commun., 2013, 49, 6900 DOI: 10.1039/C3CC43947J

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