Issue 71, 2013
From the journal:

Chemical Communications

Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides†

Yoshihiro Miyake,a   Shin-ichi Ota,a   Masashi Shibata,a   Kazunari Nakajimaa  and  Yoshiaki Nishibayashi*a  

* Corresponding authors

a Institute of Engineering Innovation, School of Engineering, The University of Tokyo, Yayoi, Bunkyo-ku, Tokyo, Japan
E-mail: ynishiba@sogo.t.u-tokyo.ac.jp
Fax: +81 3-5841-1175
Tel: +81 3-5841-1175

Abstract

Reactions of propargylic halides with trifluoromethyltrimethylsilane in the presence of a catalytic amount of copper(I) thiophene-2-carboxylate (CuTC) have been found to give the corresponding trifluoromethylated products in good to high yields with a high selectivity.

Graphical abstract: Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides

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Article information

DOI
https://doi.org/10.1039/C3CC44434A
Article type
Communication
Submitted
13 Jun 2013
Accepted
03 Jul 2013
First published
04 Jul 2013
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2013,49, 7809-7811

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Copper-catalyzed nucleophilic trifluoromethylation of propargylic halides

Y. Miyake, S. Ota, M. Shibata, K. Nakajima and Y. Nishibayashi, Chem. Commun., 2013, 49, 7809 DOI: 10.1039/C3CC44434A

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