Issue 72, 2013
From the journal:

Chemical Communications

Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals†

Minjeong Kim,a   Sung-Kyun Ko,a   Hyemi Kim,a   Injae Shin*a  and  Jinsung Tae*a  

* Corresponding authors

a Department of Chemistry, Yonsei University, Seoul 120-749, Korea
E-mail: jstae@yonsei.ac.kr, injae@yonsei.ac.kr
Fax: +82 2-364-7050
Tel: +82 2-2123-2603

Abstract

A new rhodamine fluorescent probe for monitoring ˙OH has been developed based on the oxidative C–H abstraction reaction of rhodamine cyclic hydrazide. The probe exhibits excellent selectivity for ˙OH with virtually no interference by other ROS/RNS species. Fluorescent imaging of A549 and RAW264.7 cells is also successfully demonstrated to detect intracellular ˙OH in live cells.

Graphical abstract: Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals

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Article information

DOI
https://doi.org/10.1039/C3CC44627A
Article type
Communication
Submitted
20 Jun 2013
Accepted
11 Jul 2013
First published
11 Jul 2013

Chem. Commun., 2013,49, 7959-7961

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Rhodamine cyclic hydrazide as a fluorescent probe for the detection of hydroxyl radicals

M. Kim, S. Ko, H. Kim, I. Shin and J. Tae, Chem. Commun., 2013, 49, 7959 DOI: 10.1039/C3CC44627A

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