Issue 76, 2013
From the journal:

Chemical Communications

Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand†

Pierre Murat,a   Michael V. Gormally,a   Debbie Sanders,b   Marco Di Antonioa  and  Shankar Balasubramanian*abc  

* Corresponding authors

a Department of Chemistry, The University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: sb10031@cam.ac.uk

b Cambridge Institute, Cancer Research UK, Li Ka Shing Center, Cambridge, UK

c School of Clinical Medicine, The University of Cambridge, Addenbrooke's Hospital, Hills Road, Cambridge, UK

Abstract

The use of a caged G-quadruplex ligand allows for transcriptional control of quadruplex-containing genes using UV light as an external trigger. An important oncogene, SRC, involved in the initiation and proliferation of epithelial tumours is shown to be significantly downregulated in cells treated by the caged ligand in synergy with UV light treatment.

Graphical abstract: Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

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Article information

DOI
https://doi.org/10.1039/C3CC44737E
Article type
Communication
Submitted
24 Jun 2013
Accepted
30 Jul 2013
First published
31 Jul 2013
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2013,49, 8453-8455

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Light-mediated in cell downregulation of G-quadruplex-containing genes using a photo-caged ligand

P. Murat, M. V. Gormally, D. Sanders, M. D. Antonio and S. Balasubramanian, Chem. Commun., 2013, 49, 8453 DOI: 10.1039/C3CC44737E

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