We engineered the structural flexibility of an α synuclein (αS) variant, PG65, together with conformation-sensitive fluorescence to create a molecular probe for rapid, specific and quantitative detection of αS oligomers, which are the major toxic aggregate forms in Parkinson’s disease.
M. Hernandez, Y. Hu and J. R. Kim, Chem. Commun., 2013, 49, 10712 DOI: 10.1039/C3CC44804E
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