Rapid microfluidic flow hydrogenation for reduction or deprotection of 18F-labeled compounds

Steven H. Liang; Thomas Lee Collier; Benjamin H. Rotstein; Rebecca Lewis; Mia Steck; Neil Vasdev

doi:10.1039/C3CC45166F

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Rapid microfluidic flow hydrogenation for reduction or deprotection of ¹⁸F-labeled compounds†

Steven H. Liang,^ab Thomas Lee Collier,^abc Benjamin H. Rotstein,^ab Rebecca Lewis,^bd Mia Steck^b and Neil Vasdev*^ab

Author affiliations

* Corresponding authors

^a Department of Radiology, Harvard Medical School, 55 Fruit Street, Boston, MA, USA 02114
E-mail: vasdev.neil@mgh.harvard.edu
Fax: +1-617-726-6165
Tel: +1-617-643-4736

^b Division of Nuclear Medicine and Molecular Imaging, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA 02114

^c Advion Inc., 10 Brown Road, Ithaca, NY, USA 14850

^d Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA 02115

Abstract

We have combined the benefits of both microfluidics and flow hydrogenation to provide facile access to previously underutilized reduction and protecting group chemistries for PET imaging applications. The rapid removal of an O-benzyl protecting group to prepare 2-[¹⁸F]fluoroquinolin-8-ol and the reduction of a nitro group in the synthesis of 4-[¹⁸F]fluoroaniline were achieved within 3 minutes.

This article is part of the themed collection: Recent Advances in Flow Synthesis and Continuous Processing

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Article information

DOI: https://doi.org/10.1039/C3CC45166F
Article type: Communication
Submitted: 09 Jul 2013
Accepted: 25 Jul 2013
First published: 29 Jul 2013

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Chem. Commun., 2013,49, 8755-8757

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Rapid microfluidic flow hydrogenation for reduction or deprotection of ¹⁸F-labeled compounds

S. H. Liang, T. L. Collier, B. H. Rotstein, R. Lewis, M. Steck and N. Vasdev, Chem. Commun., 2013, 49, 8755 DOI: 10.1039/C3CC45166F

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