Monosubstituted alkenyl amino acids for peptide “stapling”†
Abstract
Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.
* Corresponding authors
a
School of Chemistry, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
E-mail:
A.J.Wilson@leeds.ac.uk
Fax: +44 (0)113 3436565
Tel: +44 (0)113 3431409
b Astbury Centre for Structural Molecular Biology, University of Leeds, Woodhouse Lane, Leeds LS2 9JT, UK
Alkenylglycine amino acids were assessed as potential candidates for hydrocarbon stapling and shown to be effective in stapling of the BID BH3 peptide.
D. J. Yeo, S. L. Warriner and A. J. Wilson, Chem. Commun., 2013, 49, 9131 DOI: 10.1039/C3CC45231J
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