Issue 92, 2013
From the journal:

Chemical Communications

A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: selective detection and quantification†

Ting Guo,a   Lei Cui,a   Jiaoning Shen,a   Weiping Zhu,a   Yufang Xu*a  and  Xuhong Qian*a  

* Corresponding authors

a State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, China
E-mail: xhqian@ecsut.edu.cn, yfxu@ecust.edu.cn
Fax: +86 21-64252603

Abstract

A novel long-wavelength fluorescence probe NBP has been developed for the detection of nitroreductase (NTR) and hypoxia. NBP could be activated by NTR at 0.1 μM to release the fluorophore NBF and significant changes in fluorescence emission at 658 nm were observed. This feature makes it advantageous for imaging hypoxic cells with minimal endogenous interference.

Graphical abstract: A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: selective detection and quantification

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Article information

DOI
https://doi.org/10.1039/C3CC45367G
Article type
Communication
Submitted
16 Jul 2013
Accepted
24 Sep 2013
First published
25 Sep 2013

Chem. Commun., 2013,49, 10820-10822

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A highly sensitive long-wavelength fluorescence probe for nitroreductase and hypoxia: selective detection and quantification

T. Guo, L. Cui, J. Shen, W. Zhu, Y. Xu and X. Qian, Chem. Commun., 2013, 49, 10820 DOI: 10.1039/C3CC45367G

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