Synthesis of biaryl imino/keto carboxylic acids via aryl amide directed C–H activation reaction

Abstract

A novel Pd-catalysed C–H activation reaction for the synthesis of biaryl imino/keto carboxylic acids is developed. This reaction underwent aryl amide directed C–H activation ortho-acylation followed by ring closing and ring opening processes to give a range of biaryl imino/keto carboxylic acids. Our methodology features the utilization of a cheap and green oxidant (TBHP) as well as readily available aldehydes.