Issue 82, 2013
From the journal:

Chemical Communications

Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine†

Feng Wang,a   Po-Jung Jimmy Huanga  and  Juewen Liu*a  

* Corresponding authors

a Department of Chemistry, Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, Ontario, Canada
E-mail: liujw@uwaterloo.ca
Fax: +1 519 7460435
Tel: +1 519 8884567 ext. 38919

Abstract

The reaction between cisplatin and DNA is conveniently studied using fluorescently labeled oligonucleotides and gel electrophoresis; as an example of application, the inhibition of this reaction by citrate is demonstrated, which might increase selectivity of cisplatin towards guanine over adenine.

Graphical abstract: Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3CC45458D
Article type
Communication
Submitted
18 Jul 2013
Accepted
16 Aug 2013
First published
19 Aug 2013

Chem. Commun., 2013,49, 9482-9484

Permissions

Request permissions

Citrate inhibition of cisplatin reaction with DNA studied using fluorescently labeled oligonucleotides: implication for selectivity towards guanine

F. Wang, P. J. Huang and J. Liu, Chem. Commun., 2013, 49, 9482 DOI: 10.1039/C3CC45458D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements