Issue 95, 2013
From the journal:

Chemical Communications

Copper binding promotes the interaction of cisplatin with human copper chaperone Atox1†

Zhaoyong Xi,a   Wei Guo,b   Changlin Tian,c   Fuyi Wang*b  and  Yangzhong Liu*a  

* Corresponding authors

a CAS Key Laboratory of Soft Matter Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, Anhui, China
E-mail: liuyz@ustc.edu.cn
Tel: +86-551-63600874

b Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: fuyi.wang@iccas.ac.cn

c Hefei National Laboratory of Microscale Physical Sciences, School of Life Science, University of Science and Technology of China, Hefei, Anhui, China

Abstract

Cu(I) binding promotes the platination of Atox1, although cisplatin binds to the copper coordination sites. In addition, Cu(I) binding enhances the competition of Atox1 with DTT in the reaction of cisplatin. These results indicate that cuprous ions could regulate the cellular trafficking of cisplatin.

Graphical abstract: Copper binding promotes the interaction of cisplatin with human copper chaperone Atox1

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Article information

DOI
https://doi.org/10.1039/C3CC45905E
Article type
Communication
Submitted
02 Aug 2013
Accepted
13 Sep 2013
First published
16 Sep 2013

Chem. Commun., 2013,49, 11197-11199

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Copper binding promotes the interaction of cisplatin with human copper chaperone Atox1

Z. Xi, W. Guo, C. Tian, F. Wang and Y. Liu, Chem. Commun., 2013, 49, 11197 DOI: 10.1039/C3CC45905E

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