An adhesive 19F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment

Tomohiro Doura; Ryunosuke Hata; Hiroshi Nonaka; Fuminori Sugihara; Yoshichika Yoshioka; Shinsuke Sando

doi:10.1039/C3CC46471G

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An adhesive ¹⁹F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment†

Tomohiro Doura,‡^a Ryunosuke Hata,‡^a Hiroshi Nonaka,^a Fuminori Sugihara,^b Yoshichika Yoshioka^b and Shinsuke Sando*^a

Author affiliations

* Corresponding authors

^a INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka, Japan
E-mail: ssando@ifrc.kyushu-u.ac.jp
Fax: +81 92 802 6961
Tel: +81 92 802 6960

^b Immunology Frontier Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka, Japan

Abstract

We report a new strategy for designing a signal off-to-on-type ¹⁹F MRI chemical probe that operates in biological environments. The present strategy is based on the control of adherence of a ¹⁹F MRI chemical probe to certain blood proteins, accompanied by a change in transverse relaxation time of ¹⁹F nuclei.

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Article information

DOI: https://doi.org/10.1039/C3CC46471G
Article type: Communication
Submitted: 24 Aug 2013
Accepted: 14 Oct 2013
First published: 29 Oct 2013

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Chem. Commun., 2013,49, 11421-11423

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An adhesive ¹⁹F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment

T. Doura, R. Hata, H. Nonaka, F. Sugihara, Y. Yoshioka and S. Sando, Chem. Commun., 2013, 49, 11421 DOI: 10.1039/C3CC46471G

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Chemical Communications