γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery

Abstract

The stability and compatibility of designed coiled coil peptides towards the selective incorporation of γ⁴-amino acids at the hydrophobic positions of the heptad repeat are studied. Investigations reveal that the low thermal denaturation temperature of γ⁴-residue mutated coiled coils can be utilized as a mild hyperthermia trigger in liposomes.