Blue two-photon fluorescence metal cluster probe precisely marking cell nuclei of two cell lines

Yaling Wang; Yanyan Cui; Ru Liu; Yueteng Wei; Xinglu Jiang; Huarui Zhu; Liang Gao; Yuliang Zhao; Zhifang Chai; Xueyun Gao

doi:10.1039/C3CC46690F

Blue two-photon fluorescence metal cluster probe precisely marking cell nuclei of two cell lines†

Yaling Wang,‡^a Yanyan Cui,‡^a Ru Liu,^a Yueteng Wei,^a Xinglu Jiang,^a Huarui Zhu,^a Liang Gao,^a Yuliang Zhao,^a Zhifang Chai^ab and Xueyun Gao*^a

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^a Lab for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, P. R. China
E-mail: gaoxy@ihep.ac.cn
Fax: +86-10-88236456
Tel: +86-10-88236709

^b School of Radiological & Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou 215123, P. R. China

Abstract

A bifunctional peptide was designed to in situ reduce Cu ions and anchor a Cu cluster. The peptide–Cu cluster probe, mainly composed of Cu₁₄, emitted blue two-photon fluorescence under femtosecond laser excitation. Most important, the probe can specifically mark the nuclei of HeLa and A549 cells, respectively.

Chemical Communications

Blue two-photon fluorescence metal cluster probe precisely marking cell nuclei of two cell lines†

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Blue two-photon fluorescence metal cluster probe precisely marking cell nuclei of two cell lines

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