Issue 94, 2013
From the journal:

Chemical Communications

Copper-catalyzed ortho-halogenation of protected anilines†

Beatriz Urones,a   Ángel Manu Martínez,a   Nuria Rodríguez,*a   Ramón Gómez Arrayás*a  and  Juan C. Carretero*a  

* Corresponding authors

a Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain
E-mail: n.rodriguez@uam.es, ramon.gomez@uam.es, juancarlos.carretero@uam.es

Abstract

A practical Cu-catalyzed direct ortho-halogenation of anilines under aerobic conditions has been developed. The reaction shows typically excellent mono-substitution selectivity, high ortho-regiocontrol and large functional group tolerance.

Graphical abstract: Copper-catalyzed ortho-halogenation of protected anilines

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Article information

DOI
https://doi.org/10.1039/C3CC47174H
Article type
Communication
Submitted
19 Sep 2013
Accepted
05 Oct 2013
First published
07 Oct 2013

Chem. Commun., 2013,49, 11044-11046

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Copper-catalyzed ortho-halogenation of protected anilines

B. Urones, Á. M. Martínez, N. Rodríguez, R. G. Arrayás and J. C. Carretero, Chem. Commun., 2013, 49, 11044 DOI: 10.1039/C3CC47174H

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