Application of hydrogen-bond propensity calculations to an indomethacin–nicotinamide (1 : 1) co-crystal

Mridul Majumder; Graham Buckton; Clare F. Rawlinson-Malone; Adrian C. Williams; Mark J. Spillman; Elna Pidcock; Kenneth Shankland

doi:10.1039/C3CE40367J

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Application of hydrogen-bond propensity calculations to an indomethacin–nicotinamide (1 : 1) co-crystal†

Mridul Majumder,^ab Graham Buckton,^c Clare F. Rawlinson-Malone,^d Adrian C. Williams,^b Mark J. Spillman,^b Elna Pidcock^e and Kenneth Shankland*^b

Author affiliations

* Corresponding authors

^a Pharmaterials Ltd., Unit B, 5 Boulton Road, Reading RG2 0NH, UK
E-mail: mridul.majumder@pharmaterials.co.uk
Fax: +44 (0)1189 310679
Tel: +44 (0)1189 209900

^b School of Pharmacy, University of Reading, Whiteknights, Reading RG6 6AD, UK

^c UCL School of Pharmacy, 29–39 Brunswick Square, London WC1N 1AX, UK

^d Bristol-Myers Squibb Pharmaceuticals Limited, Reeds Lane, Moreton, CH46 1QW, UK

^e Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge, CB2 1EZ, UK

Abstract

The crystal structure of an indomethacin–nicotinamide (1 : 1) co-crystal produced by milling has been determined from laboratory powder X-ray diffraction (PXRD) data. The hydrogen bonding motifs observed in the structure represent one of the most probable of all the possible combinations of donors and acceptors in the constituent molecules.

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Article information

DOI: https://doi.org/10.1039/C3CE40367J
Article type: Communication
Submitted: 28 Feb 2013
Accepted: 08 Apr 2013
First published: 08 Apr 2013

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CrystEngComm, 2013,15, 4041-4044

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Application of hydrogen-bond propensity calculations to an indomethacin–nicotinamide (1 : 1) co-crystal

M. Majumder, G. Buckton, C. F. Rawlinson-Malone, A. C. Williams, M. J. Spillman, E. Pidcock and K. Shankland, CrystEngComm, 2013, 15, 4041 DOI: 10.1039/C3CE40367J

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