Modulating water-exchange rates of lanthanide(iii)-containing polyaminopolycarboxylate-type complexes using polyethylene glycol

Abstract

We have synthesized a series of Ln^III-containing polyethylene glycol conjugates and studied the structural and electronic properties of these complexes. These studies demonstrate that polyethylene glycol can be used to fine-tune water-exchange rates of Ln^III-containing polyaminopolycarboxylate-type complexes; this control is desirable in developing Ln^III-containing contrast agents for magnetic resonance imaging.