Issue 3, 2013
From the journal:

Lab on a Chip

Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays†

Claudio Parolo,a   Mariana Medina-Sánchez,a   Alfredo de la Escosura-Muñiza  and  Arben Merkoçi*ab  

* Corresponding authors

a Nanobioelectronics & Biosensors Group, Institut Català de Nanotecnologia, CIN2 (ICN-CSIC), Campus UAB, Barcelona, Spain

b ICREA, Barcelona, Spain
E-mail: arben.merkoci@icn.cat

Abstract

Lateral flow immunoassays (LFIA) are ideal biosensors to detect proteins, but their lack of sensitivity hinders their extensive use. We report a strategy that yields up to an 8-fold improvement in the sensitivity of a gold nanoparticles-based LFIA by changing the sizes of the pads. Theoretical flow simulations of the developed LFIA architectures are in accordance with the experimental results.

Graphical abstract: Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

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Article information

DOI
https://doi.org/10.1039/C2LC41144J
Article type
Paper
Submitted
11 Oct 2012
Accepted
25 Oct 2012
First published
26 Oct 2012

Lab Chip, 2013,13, 386-390

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Simple paper architecture modifications lead to enhanced sensitivity in nanoparticle based lateral flow immunoassays

C. Parolo, M. Medina-Sánchez, A. de la Escosura-Muñiz and A. Merkoçi, Lab Chip, 2013, 13, 386 DOI: 10.1039/C2LC41144J

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