Issue 1, 2013
From the journal:

Organic & Biomolecular Chemistry

Investigations regarding the utility of prodigiosenes to treat leukemia†

Deborah A. Smithen,a   A. Michael Forrester,bc   Dale P. Corkery,d   Graham Dellaire,de   Julie Colpitts,f   Sherri A. McFarland,f   Jason N. Bermanbcg  and  Alison Thompson*a  

* Corresponding authors

a Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada
E-mail: alison.thompson@dal.ca

b Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada

c IWK Health Centre, Halifax, Nova Scotia, Canada

d Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada

e Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada

f Department of Chemistry, Acadia University, Wolfville, Nova Scotia, Canada

g Department of Pediatrics, Dalhousie University, P.O. Box 15000, Halifax, Nova Scotia, Canada

Abstract

Prodigiosenes, possessing a 4-methoxypyrrolyldipyrrin skeleton, are known for their anti-cancer activity. Structural modification of the C-ring resulted in a series of prodigiosenes that displayed promising activity against leukemia cell lines during in vitro analysis against the NCI 60 cancer cell line panel. Further in vivo studies of these compounds using the zebrafish model showed persistence of anti-leukemia properties in human K562 chronic myelogenous leukemia cells.

Graphical abstract: Investigations regarding the utility of prodigiosenes to treat leukemia

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Article information

DOI
https://doi.org/10.1039/C2OB26535D
Article type
Paper
Submitted
03 Aug 2012
Accepted
02 Oct 2012
First published
15 Oct 2012

Org. Biomol. Chem., 2013,11, 62-68

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Investigations regarding the utility of prodigiosenes to treat leukemia

D. A. Smithen, A. M. Forrester, D. P. Corkery, G. Dellaire, J. Colpitts, S. A. McFarland, J. N. Berman and A. Thompson, Org. Biomol. Chem., 2013, 11, 62 DOI: 10.1039/C2OB26535D

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