Issue 6, 2013

A highly enantioselective Darzens reaction between diazoacetamides and aldehydes catalyzed by a (+)-pinanediol–Ti(OiPr)4 system

Abstract

A highly efficient enantioselective Darzens reaction of aldehydes with diazoacetamides catalyzed by a (+)-pinanediol–Ti(OiPr)4 system has been developed. The cis-glycidic amides were obtained in high yields and with moderate to excellent enantioselectivity (up to 99%).

Graphical abstract: A highly enantioselective Darzens reaction between diazoacetamides and aldehydes catalyzed by a (+)-pinanediol–Ti(OiPr)4 system

Supplementary files

Article information

Article type
Communication
Submitted
09 Nov 2012
Accepted
19 Dec 2012
First published
20 Dec 2012

Org. Biomol. Chem., 2013,11, 900-904

A highly enantioselective Darzens reaction between diazoacetamides and aldehydes catalyzed by a (+)-pinanediol–Ti(OiPr)4 system

G. Liu, D. Zhang, J. Li, G. Xu and J. Sun, Org. Biomol. Chem., 2013, 11, 900 DOI: 10.1039/C2OB27179F

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