Issue 8, 2013
From the journal:

Organic & Biomolecular Chemistry

Cu-catalyzed direct C–H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles†

Zengyang Xie,a   Xiaojun Zhu,a   Yangfan Guan,a   Dunru Zhu,b   Hongwen Hu,a   Chen Lin,a   Yi Pan,a   Juli Jiang*a  and  Leyong Wanga  

* Corresponding authors

a Key Laboratory of Mesoscopic Chemistry of Ministry of Education, Center for Multimolecular Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, P. R. China
E-mail: jjl@nju.edu.cn
Fax: +86 (25) 83597090
Tel: +86 (25) 83597090

b State Key Laboratory of Material-Oriented Chemical Engineering, College of Chemistry and Chemical Engineering, Nanjing University of Technology, Nanjing, P. R. China

Abstract

An efficient, regioselective C-5 arylation of thiazolo[3,2-b]-1,2,4-triazoles catalyzed by a simple copper catalyst was developed. This arylation proceeded smoothly and tolerated a variety of functional groups (44 examples). A wide range of functionalized thiazolo[3,2-b]-1,2,4-triazole derivatives were obtained in high yields (up to 99% yield). Possible catalytic cycles of the arylation were also discussed.

Graphical abstract: Cu-catalyzed direct C–H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles

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Article information

DOI
https://doi.org/10.1039/C2OB27326H
Article type
Paper
Submitted
10 Oct 2012
Accepted
03 Dec 2012
First published
12 Dec 2012

Org. Biomol. Chem., 2013,11, 1390-1398

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Cu-catalyzed direct C–H bond functionalization: a regioselective protocol to 5-aryl thiazolo[3,2-b]-1,2,4-triazoles

Z. Xie, X. Zhu, Y. Guan, D. Zhu, H. Hu, C. Lin, Y. Pan, J. Jiang and L. Wang, Org. Biomol. Chem., 2013, 11, 1390 DOI: 10.1039/C2OB27326H

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