Issue 13, 2013
From the journal:

Organic & Biomolecular Chemistry

Iron-catalyzed N-alkylation using π-activated ethers as electrophiles†

Xiaohui Fan,*a   Lin-An Fu,a   Na Li,a   Hao Lv,a   Xiao-Meng Cuia  and  Yuan Qia  

* Corresponding authors

a School of Chemical and Biological Engineering, Lanzhou Jiaotong University, Lanzhou, China
E-mail: fanxh@mail.lzjtu.cn
Fax: +86 931 493 8755
Tel: +86 931 493 8755

Abstract

A new method for the synthesis of diverse N-alkylation compounds was developed via an iron-catalyzed etheric Csp3–O cleavage with the C–N bond formation in the reaction of π-activated ethers with various nitrogen-based nucleophiles. In addition, the mechanism of this reaction was investigated.

Graphical abstract: Iron-catalyzed N-alkylation using π-activated ethers as electrophiles

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Article information

DOI
https://doi.org/10.1039/C3OB27128E
Article type
Paper
Submitted
31 Oct 2012
Accepted
16 Jan 2013
First published
17 Jan 2013

Org. Biomol. Chem., 2013,11, 2147-2153

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Iron-catalyzed N-alkylation using π-activated ethers as electrophiles

X. Fan, L. Fu, N. Li, H. Lv, X. Cui and Y. Qi, Org. Biomol. Chem., 2013, 11, 2147 DOI: 10.1039/C3OB27128E

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