Issue 19, 2013
From the journal:

Organic & Biomolecular Chemistry

In-stem labelling allows visualization of DNA strand displacements by distinct fluorescent colour change†

Sebastian Barroisa  and  Hans-Achim Wagenknecht*a  

* Corresponding authors

a Institute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany
E-mail: Wagenknecht@kit.edu
Fax: +49-721-608-44825
Tel: +49-721-608-47486

Abstract

The combination of thiazole orange (TO) and thiazole red (TR) as an internal pair of fluorescent DNA base surrogates (“DNA traffic lights”) allows us to follow at least two consecutive DNA strand displacements in real time through a distinct fluorescence colour change from green to red and vice versa.

Graphical abstract: In-stem labelling allows visualization of DNA strand displacements by distinct fluorescent colour change

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Article information

DOI
https://doi.org/10.1039/C3OB40435H
Article type
Communication
Submitted
01 Mar 2013
Accepted
22 Mar 2013
First published
22 Mar 2013

Org. Biomol. Chem., 2013,11, 3085-3088

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In-stem labelling allows visualization of DNA strand displacements by distinct fluorescent colour change

S. Barrois and H. Wagenknecht, Org. Biomol. Chem., 2013, 11, 3085 DOI: 10.1039/C3OB40435H

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