Issue 22, 2013
From the journal:

Organic & Biomolecular Chemistry

Silver-catalyzed amidation of benzoylformic acids with tertiary aminesvia selective carbon–nitrogen bond cleavage†

Xiaobin Zhang,a   Wenchao Yanga  and  Lei Wang*ab  

* Corresponding authors

a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China
E-mail: leiwang@chnu.edu.cn
Fax: +86-561-309-0518
Tel: +86-561-380-2069

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China

Abstract

A novel approach towards the synthesis of α-ketoamides using tertiary amines as nitrogen group sources via C–N bond cleavage has been developed. In the presence of Ag2CO3 and K2S2O8, α-keto acids reacted with tertiary amines to afford the corresponding α-ketoamides in good yields.

Graphical abstract: Silver-catalyzed amidation of benzoylformic acids with tertiary amines via selective carbon–nitrogen bond cleavage

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Article information

DOI
https://doi.org/10.1039/C3OB40619A
Article type
Paper
Submitted
28 Mar 2013
Accepted
30 Mar 2013
First published
08 Apr 2013

Org. Biomol. Chem., 2013,11, 3649-3654

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Silver-catalyzed amidation of benzoylformic acids with tertiary amines via selective carbon–nitrogen bond cleavage

X. Zhang, W. Yang and L. Wang, Org. Biomol. Chem., 2013, 11, 3649 DOI: 10.1039/C3OB40619A

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