Issue 30, 2013
From the journal:

Organic & Biomolecular Chemistry

E-Factor minimized hydrophosphonylation of aldehydes catalyzed by polystyryl-BEMP under solvent-free conditions†

Tommaso Angelini,a   Simona Bonollo,a   Daniela Lanari,*a   Ferdinando Pizzoa  and  Luigi Vaccaro*a  

* Corresponding authors

a Laboratory of Green Synthetic Organic Chemistry, CEMIN – Dipartimento di Chimica, Università di Perugia Via Elce di Sotto, 8, Perugia, Italia
E-mail: luigi@unipg.it
Fax: +39 075 5855560
Tel: +39 075 5855541

Abstract

An efficient protocol for the hydrophosphonylation of aromatic and aliphatic aldehydes catalyzed by PS-BEMP under solvent-free conditions (SolFC) has been reported. Addition reactions were performed by using equimolar amounts of reagents and the resulting α-hydroxyphosphonates were isolated with simple workup procedures. A large scale protocol for the preparation of a representative α-hydroxyphosphonate 3a has been also set up using a flow reactor.

Graphical abstract: E-Factor minimized hydrophosphonylation of aldehydes catalyzed by polystyryl-BEMP under solvent-free conditions

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C3OB40767E
Article type
Paper
Submitted
17 Apr 2013
Accepted
31 May 2013
First published
03 Jun 2013

Org. Biomol. Chem., 2013,11, 5042-5046

Permissions

Request permissions

E-Factor minimized hydrophosphonylation of aldehydes catalyzed by polystyryl-BEMP under solvent-free conditions

T. Angelini, S. Bonollo, D. Lanari, F. Pizzo and L. Vaccaro, Org. Biomol. Chem., 2013, 11, 5042 DOI: 10.1039/C3OB40767E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements