Issue 39, 2013

Highly efficient synthesis of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates

Abstract

A highly efficient synthesis of a wide range of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates is described. The reactions are conducted under convenient conditions and provide products with excellent regioselectivity in moderate to excellent yields with a broad substrate scope, including a variety of aromatic and aliphatic haloenol acetates.

Graphical abstract: Highly efficient synthesis of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates

Supplementary files

Article information

Article type
Communication
Submitted
06 Jun 2013
Accepted
10 Aug 2013
First published
14 Aug 2013

Org. Biomol. Chem., 2013,11, 6699-6702

Highly efficient synthesis of 2,5-disubstituted pyrazines from (Z)-β-haloenol acetates

Z. Chen, D. Ye, G. Xu, M. Ye and L. Liu, Org. Biomol. Chem., 2013, 11, 6699 DOI: 10.1039/C3OB41164H

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