Issue 6, 2013
From the journal:

RSC Advances

Computer aided design of FtsZ targeting oligopeptides†

Stefano Pieraccini,*ab   Stefano Rendine,‡a   Chacko Jobichen,‡c   Prerna Domadia,c   J. Sivaraman,c   Pierangelo Francescato,a   Giovanna Speranzaab  and  Maurizio Sironi*ab  

* Corresponding authors

a Dipartimento di Chimica and INSTM – UdR, Università degli Studi di Milano, Via Golgi 19, 20133, Milano, Italy

b Istituto di Scienze e tecnologie molecolari del CNR (CNR-ISTM), Via Golgi 19, 20133, Milano, Italy
E-mail: stefano.pieraccini@unimi.it, maurizio.sironi@unimi.it

c Department of Biological Science, National University of Singapore, 14 Science Drive 4, Singapore

Abstract

FtsZ is a protein involved in the bacterial division process and is thus an emerging target for antibacterial drugs. The network of interactions between FtsZ monomers necessary for exploitation of its biological function are studied here with molecular dynamics and free energy calculations. The results obtained led to the design of FtsZ targeting peptides which exhibited activity against the function of FtsZ in vitro.

Graphical abstract: Computer aided design of FtsZ targeting oligopeptides

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Article information

DOI
https://doi.org/10.1039/C2RA21886K
Article type
Communication
Submitted
22 Aug 2012
Accepted
11 Dec 2012
First published
21 Dec 2012

RSC Adv., 2013,3, 1739-1743

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Computer aided design of FtsZ targeting oligopeptides

S. Pieraccini, S. Rendine, C. Jobichen, P. Domadia, J. Sivaraman, P. Francescato, G. Speranza and M. Sironi, RSC Adv., 2013, 3, 1739 DOI: 10.1039/C2RA21886K

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