A novel and metal-free approach towards α-ketoamides using a TBHP/I2-promoted tandem reaction of amines with β-diketones via C–C bond cleavage

Xiaobin Zhang; Min Wang; Yicheng Zhang; Lei Wang

doi:10.1039/C2RA22116K

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A novel and metal-free approach towards α-ketoamides using a TBHP/I₂-promoted tandem reaction of amines with β-diketones via C–C bond cleavage†

Xiaobin Zhang,^a Min Wang,^a Yicheng Zhang^a and Lei Wang*^ab

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* Corresponding authors

^a Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, P R China
E-mail: leiwang@chnu.edu.cn
Fax: +86-561-309-0518
Tel: +86-561-380-2069

^b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P R China

Abstract

A novel approach towards the synthesis of α-ketoamides using a TBHP/I₂-promoted tandem reaction of amines with β-diketones via C–C bond cleavage has been developed. This one-pot reaction proceeded well under metal-free conditions and generated the corresponding products with good yields.

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Article information

DOI: https://doi.org/10.1039/C2RA22116K
Article type: Communication
Submitted: 11 Sep 2012
Accepted: 17 Nov 2012
First published: 21 Nov 2012

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RSC Adv., 2013,3, 1311-1316

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A novel and metal-free approach towards α-ketoamides using a TBHP/I₂-promoted tandem reaction of amines with β-diketones via C–C bond cleavage

X. Zhang, M. Wang, Y. Zhang and L. Wang, RSC Adv., 2013, 3, 1311 DOI: 10.1039/C2RA22116K

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