Issue 6, 2013

Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

Abstract

Photoresponsive oligonucleotides (ONs) incorporating isoxazole-linked azobenzene (AB) moieties were prepared by resin-supported nitrile oxide-alkyne cycloaddition (NOAC) chemistry. The thermal and photochromic properties of the modified ONs were significantly influenced by the extent of π-conjugation between the isoxazole and the AB modules.

Graphical abstract: Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

Supplementary files

Article information

Article type
Communication
Submitted
08 Nov 2012
Accepted
20 Nov 2012
First published
11 Dec 2012

RSC Adv., 2013,3, 1652-1655

Oligo switches: photoresponsive oligonucleotide conjugates by solid-supported click chemistry

C. Freeman, J. S. Vyle and F. Heaney, RSC Adv., 2013, 3, 1652 DOI: 10.1039/C2RA22815G

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