Issue 18, 2013
From the journal:

RSC Advances

Accommodating fluorinated amino acids in a helical peptide environment†

Elisabeth K. Nyakatura,a   Oliver Reimann,a   Toni Vagt,b   Mario Salwiczeka  and  Beate Koksch*a  

* Corresponding authors

a Institute of Chemistry and Biochemistry-Organic Chemistry, Freie Universiät Berlin, Takustraße 3, Berlin, Germany
E-mail: koksch@chemie.fu-berlin.de

b Institute of Molecular Biology and Biophysics, ETH, Zürich, CH-8093 Zürich, Switzerland

Abstract

Fluorinated amino acids represent useful building blocks for structural and functional upgrading of peptides and proteins. Here, we report the identification of a suitable environment for fluorinated aminobutyric acids in a central d-position of a heterodimeric coiled-coil assembly via phage display.

Graphical abstract: Accommodating fluorinated amino acids in a helical peptide environment

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Article information

DOI
https://doi.org/10.1039/C3RA41110A
Article type
Communication
Submitted
05 Nov 2012
Accepted
07 Mar 2013
First published
14 Mar 2013

RSC Adv., 2013,3, 6319-6322

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Accommodating fluorinated amino acids in a helical peptide environment

E. K. Nyakatura, O. Reimann, T. Vagt, M. Salwiczek and B. Koksch, RSC Adv., 2013, 3, 6319 DOI: 10.1039/C3RA41110A

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