Issue 38, 2013
From the journal:

RSC Advances

A simple fluorescent assay for lead(ii) detection based on lead(ii)-stabilized G-quadruplex formation†

Shenshan Zhan,ac   Yuangen Wu,ac   Le Liu,bc   Haibo Xing,ac   Lan He,ac   Xuejia Zhan,bc   Yanfang Luobc  and  Pei Zhou*abc  

* Corresponding authors

a School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, China
E-mail: zhoupei@sjtu.edu.cn
Fax: +86-21-34205762
Tel: +86-21-34205762

b School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China

c Key Laboratory of Urban Agriculture (South), Ministry of Agriculture and Bor S. Luh Food Safety Research Center, Shanghai Jiao Tong University, Shanghai, China

Abstract

A fluorescence quenching result was obtained when an FAM-labelled G-rich oligonucleotide T30695 was treated with Pb2+, owing to the formation of a lead(II)-stabilized G-quadruplex. Based on this phenomenon a selective fluorescent assay for lead(II) detection with a limit of detection of 0.77 ppb and a detection range from 0 to 200 ppb was constructed.

Graphical abstract: A simple fluorescent assay for lead(ii) detection based on lead(ii)-stabilized G-quadruplex formation

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Article information

DOI
https://doi.org/10.1039/C3RA42621A
Article type
Communication
Submitted
29 May 2013
Accepted
19 Jul 2013
First published
24 Jul 2013

RSC Adv., 2013,3, 16962-16966

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A simple fluorescent assay for lead(II) detection based on lead(II)-stabilized G-quadruplex formation

S. Zhan, Y. Wu, L. Liu, H. Xing, L. He, X. Zhan, Y. Luo and P. Zhou, RSC Adv., 2013, 3, 16962 DOI: 10.1039/C3RA42621A

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