Issue 6, 2013
From the journal:

Chemical Science

Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands†

Deng-Fu Lu,a   Cheng-Liang Zhua  and  Hao Xu*a  

* Corresponding authors

a Department of Chemistry, Georgia State University, 100 Piedmont Ave SE, Atlanta, Georgia 30303, USA
E-mail: hxu@gsu.edu
Tel: +1-404-413-5553

Abstract

A diastereoselective 1,4-hydroxytrifluoromethylation of dienes is catalyzed by copper cyanide–phosphine complexes. This reaction is significantly accelerated by bulky monodentate phosphines, and the discovery enables expedient access to a variety of CF3-containing allylic alcohol derivatives.

Graphical abstract: Copper(i)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

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Article information

DOI
https://doi.org/10.1039/C3SC50582K
Article type
Edge Article
Submitted
28 Feb 2013
Accepted
19 Mar 2013
First published
20 Mar 2013

Chem. Sci., 2013,4, 2478-2482

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Copper(I)-catalyzed diastereoselective hydroxytrifluoromethylation of dienes accelerated by phosphine ligands

D. Lu, C. Zhu and H. Xu, Chem. Sci., 2013, 4, 2478 DOI: 10.1039/C3SC50582K

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