Multifunctional Pt(IV) pro-drug and its micellar platform: to kill two birds with one stone

Haiqin Song; Haihua Xiao; Yu Zhang; Haidong Cai; Rui Wang; Yonghui Zheng; Yubin Huang; Yuxin Li; Zhigang Xie; Tongjun Liu; Xiabin Jing

doi:10.1039/C2TB00206J

Multifunctional Pt(iv) pro-drug and its micellar platform: to kill two birds with one stone†

Haiqin Song,‡^a Haihua Xiao,‡^bc Yu Zhang,^d Haidong Cai,^e Rui Wang,^bc Yonghui Zheng,^a Yubin Huang,^a Yuxin Li,^e Zhigang Xie,^b Tongjun Liu*^a and Xiabin Jing*^b

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* Corresponding authors

^a Department of Colorectal and Anal Surgery, China-Japan Union Hospital of Jilin University, Changchun 130033, China
E-mail: tjliu@jlu.edu.cn
Fax: +86-431-89816798
Tel: +86-431-89816798

^b State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
E-mail: xbjing@ciac.jl.cn
Fax: +86-431-85262775
Tel: +86-431-85262775

^c Graduate School of Chinese Academy of Sciences, Beijing 100049, China

^d National Engineering Laboratory for Druggable Gene and Protein Screening, Northeast Normal University, Changchun 130024, People's Republic of China

^e Department of Chemistry and Environmental Engineering, Changchun University of Science and Technology, Changchun 130022, China

Abstract

A multifunctional hybrid platinum(IV) drug which has both DCA and Pt in one molecule was synthesized and tethered to polymers to further self-assemble into micelles. This micelle-mediated delivery of platinum(IV) prodrug aims to target both nuclear DNA and mitochondria.

Journal of Materials Chemistry B

Multifunctional Pt(iv) pro-drug and its micellar platform: to kill two birds with one stone†

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Multifunctional Pt(IV) pro-drug and its micellar platform: to kill two birds with one stone

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